Intestinal Organoids
Not applicable · Testing additional biopsies · 1 site · Rennes University Hospital
Official record & contacts on ClinicalTrials.gov ↗
In plain English
What this trial is testing
This study is testing additional biopsies (a procedure). Condition(s) listed: Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type and Crohn Disease.
It is open-label: participants know what they are receiving.
This study does not use drug-development phases (it may test a device, diet, procedure, app, or care approach).
Who can join
- Ages 18 to 75
- Any sex
Some of the main requirements, copied from the record:
- Subjects aged 18 to 75 years
- Subject undergoing endoscopy as part of the standard of care with the need to take digestive biopsy samples
- Subject having signed a free and informed consent in writing
There are also 2 reasons someone might not be able to join (exclusion criteria). Only the trial team can confirm whether you qualify.
What's involved
- About 90 participants are expected to take part.
- Start date: 2022-09-06.
- Main results expected around 2028-03-07 (estimate from the record).
- 1 study site listed (1 marked recruiting) in France.
Main thing being measured
- Number of isolated intestinal crypts per biopsies (Day 0)
In the researchers’ words
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell lines, immortalized cells) since they preserve in culture the functional complexity present in vivo (architecture, different cell types).
This is a short automatic summary built from the official record. A fuller plain-English card is coming; until then, please read the official record.
Questions to ask your doctor and the trial team
- Am I likely to qualify, given my health history?
- What would I have to do, and how often would I need to visit?
- Could I get a placebo? What happens to my current treatment?
- What are the possible risks and benefits?
- Are travel or other costs covered?
- What happens after the trial ends?
Official details
| Status | Recruiting |
|---|---|
| Phase | Not applicable |
| Study type | Interventional |
| Conditions | Digestive System Diseases; Inflammatory Bowel Disease, Ulcerative Colitis Type; Crohn Disease |
| Lead sponsor | Rennes University Hospital |
| Enrollment | 90 (estimated) |
| Start date | 2022-09-06 |
| Primary completion (est.) | 2028-03-07 |
| First posted | 2022-03-24 |
| Last updated | 2026-06-17 |
| Official title | Intestinal Organoids |
| ClinicalTrials.gov ID | NCT05294107 |
Interventions
- additional biopsies (Procedure)
After Verification of eligibility criteria, patient information and consent, digestive biopsies performed for the study are in addition to those performed for the patient's follow-up: * 6 biopsies are taken on average in clinical routine * 4 additional biopsies are necessary to obtain a sufficient number of amplifiable stem cells The samples will be sent within one hour to the Biological Resource…
Full eligibility criteria (from the record)
Inclusion Criteria: * Subjects aged 18 to 75 years * Subject undergoing endoscopy as part of the standard of care with the need to take digestive biopsy samples * Subject having signed a free and informed consent in writing Exclusion Criteria: * Subjects under legal protection (safeguard of justice, curatorship or guardianship) or deprived of liberty. * Anticoagulant treatment and anti-platelet treatment (except for aspirin 75 mg)
Locations (1)
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de RENNES-Service des Maladies de l'Appareil Digestif | Rennes | France | Recruiting |
For contacts at each site, use the official record.
Information only, not medical advice. Talk to your doctor and the trial team before making any decision about a clinical trial.