Neural Circuit Mechanism of Inflammatory Bowel Disease Combined With Depression
Observational · No treatment assigned · Sites not listed yet · LanZhou University
Official record & contacts on ClinicalTrials.gov ↗
In plain English
What this trial is testing
Condition(s) listed: Inflammatory Bowel Diseases. This is an observational study: researchers collect information (for example questionnaires, samples, or scans) but the study does not assign a treatment.
Who can join
- Ages 18 to 65
- Any sex
- Healthy volunteers accepted
Some of the main requirements, copied from the record:
- aged 18-65 years right-handed active disease (CDAI score ≥150, Mayo score >2).
There are also 1 reasons someone might not be able to join (exclusion criteria). Only the trial team can confirm whether you qualify.
What's involved
- About 100 participants are expected to take part.
- Start date: 2024-07-01 (planned).
- Main results expected around 2024-07-01 (estimate from the record).
- No study sites are listed yet. Check the official record for contact details.
Main thing being measured
- Magnetic resonance spectroscopy (1 week before and 1 week after FMT)
In the researchers’ words
The goal of this observational study is to understand the effects of gut microbiota dysbiosis treatment in patients with inflammatory bowel disease (IBD) combined with depression. The main question it aims to answer is: Does fecal microbiota transplantation (FMT) improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex?
This is a short automatic summary built from the official record. A fuller plain-English card is coming; until then, please read the official record.
Questions to ask your doctor and the trial team
- Am I likely to qualify, given my health history?
- What would I have to do, and how often would I need to visit?
- Could I get a placebo? What happens to my current treatment?
- What are the possible risks and benefits?
- Are travel or other costs covered?
- What happens after the trial ends?
Official details
| Status | Not yet recruiting |
|---|---|
| Phase | Observational |
| Study type | Observational |
| Conditions | Inflammatory Bowel Diseases |
| Lead sponsor | LanZhou University |
| Enrollment | 100 (estimated) |
| Start date | 2024-07-01 |
| Primary completion (est.) | 2024-07-01 |
| First posted | 2024-06-24 |
| Last updated | 2024-06-25 |
| Official title | Study on the Neural Circuit Mechanism of Regulating GABA by Gut Microbiota in Inflammatory Bowel Disease Combined With Depression |
| ClinicalTrials.gov ID | NCT06471894 |
Interventions
- Magnetic resonance imaging scanning (Radiation)
Perform brain diffusion imaging, magnetic resonance spectroscopy, and functional magnetic resonance imaging scans on all individuals - FMT Protocol (Drug)
Treatment of disease groups (UC and CD) using prepared fecal microbiota transplantation solution
Full eligibility criteria (from the record)
Inclusion Criteria: aged 18-65 years right-handed active disease (CDAI score ≥150, Mayo score >2). Exclusion Criteria: previous brain surgery those with severe and unstable physical diseases those with contraindications for MRI who cannot tolerate long-duration MRI examinations.
Locations (0)
No sites listed yet. The official record has contact information.
For contacts at each site, use the official record.
Information only, not medical advice. Talk to your doctor and the trial team before making any decision about a clinical trial.