Diagnostic Concordance of MR Enterography and Ultrasound for Treatment Response Assessment in Crohn's Disease (MANTRA)
Observational · No treatment assigned · 1 site · University College, London
Official record & contacts on ClinicalTrials.gov ↗
In plain English
What this trial is testing
Condition(s) listed: Crohn Disease. This is an observational study: researchers collect information (for example questionnaires, samples, or scans) but the study does not assign a treatment.
Who can join
- Ages 16 to 99
- Any sex
Some of the main requirements, copied from the record:
- Small bowel or colonic Crohn's disease
- 16 years or older
- Baseline/pre-treatment MR Enterography or Intestinal Ultrasound already performed as part of standard clinical care
Plus 1 more requirement(s). There are also 4 reasons someone might not be able to join (exclusion criteria). Only the trial team can confirm whether you qualify.
What's involved
- About 155 participants are expected to take part.
- Start date: 2024-10-04.
- Main results expected around 2026-10-01 (estimate from the record).
- 1 study site listed (1 marked recruiting) in United Kingdom.
Main thing being measured
- Primary Outcome Measure (18 months)
In the researchers’ words
Crohn's disease is a lifelong condition resulting in inflammation of the bowel. Treatment with powerful drugs aim to reduce inflammation by suppressing the immune system.
This is a short automatic summary built from the official record. A fuller plain-English card is coming; until then, please read the official record.
Questions to ask your doctor and the trial team
- Am I likely to qualify, given my health history?
- What would I have to do, and how often would I need to visit?
- Could I get a placebo? What happens to my current treatment?
- What are the possible risks and benefits?
- Are travel or other costs covered?
- What happens after the trial ends?
Official details
| Status | Recruiting |
|---|---|
| Phase | Observational |
| Study type | Observational |
| Conditions | Crohn Disease |
| Lead sponsor | University College, London |
| Enrollment | 155 (estimated) |
| Start date | 2024-10-04 |
| Primary completion (est.) | 2026-10-01 |
| First posted | 2025-01-30 |
| Last updated | 2025-01-30 |
| Official title | Diagnostic Concordance of MR Enterography and Ultrasound for Treatment Response Assessment in Crohn's Disease (MANTRA): a Multicentre, Non-randomised, Multiple-arm, Prospective Cohort Comparison Study |
| ClinicalTrials.gov ID | NCT06800326 |
Interventions
- Ultrasound (Diagnostic Test)
Participants will have either an ultrasound or magnetic resonance imaging, depending on what scan they have had as part of their standard of care. - MRE Scan (Diagnostic Test)
Participants will have either an ultrasound or magnetic resonance imaging, depending on what scan they have had as part of their standard of care.
Full eligibility criteria (from the record)
Inclusion Criteria: * Small bowel or colonic Crohn's disease * 16 years or older * Baseline/pre-treatment MR Enterography or Intestinal Ultrasound already performed as part of standard clinical care * Follow up MR Enterography or Intestinal Ultrasound requested to assess treatment response within 15 months of baseline/ pre-treatment imaging Exclusion Criteria: * Interval resection of diseased segment(s) * Inability to achieve informed consent * Pregnancy * Any contraindication/ intolerance to MRI
Locations (1)
| Site | City | Country | Site status |
|---|---|---|---|
| University College London Hospitals | London | United Kingdom | Recruiting |
For contacts at each site, use the official record.
Information only, not medical advice. Talk to your doctor and the trial team before making any decision about a clinical trial.