Study of Tissue Repair in Inflammatory Bowel Disease Exploiting Organoid Technology
Not applicable · Testing Colonoscopy - IBD inflamed tissue, Surgical resection - IBD inflamed mucous membrane and… · 1 site · Assistance Publique Hopitaux De Marseille
Official record & contacts on ClinicalTrials.gov ↗
In plain English
What this trial is testing
This study is testing Colonoscopy - IBD inflamed tissue (a procedure), Surgical resection - IBD inflamed mucous membrane (a procedure), Colonoscopy - biopsies in healthy tissue (a procedure) and Surgical resection - healthy mucous membrane (a procedure) to better understand how the disease works. Condition(s) listed: Crohn Disease, Inflammatory Bowel Diseases (IBD) and Ulcerative Colitis (Disorder).
It is open-label: participants know what they are receiving.
This study does not use drug-development phases (it may test a device, diet, procedure, app, or care approach).
Who can join
- Ages 18 and older
- Any sex
Some of the main requirements, copied from the record:
- For IBD group the inclusion criteria will be:
- Patients of either sex aged 18 years or older
- Patient that have read the information form and signed consent
Plus 28 more requirement(s). Only the trial team can confirm whether you qualify.
What's involved
- About 60 participants are expected to take part.
- Start date: 2025-07-24.
- Main results expected around 2027-03-24 (estimate from the record).
- 1 study site listed (1 marked recruiting) in France.
Main thing being measured
- Repair status of IBD patient's epithelial cells from inflamed mucosae (From enrollmet to the end of following at 1 month)
In the researchers’ words
Inflammatory Bowel Diseases (IBD) are chronic inflammations of the gastrointestinal tract. Regardless of the etiology, a common trait of IBD pathogenesis is the inflammatory damage inflicted on the intestinal mucosa and the loss of intestinal epithelial barrier integrity.
This is a short automatic summary built from the official record. A fuller plain-English card is coming; until then, please read the official record.
Questions to ask your doctor and the trial team
- Am I likely to qualify, given my health history?
- What would I have to do, and how often would I need to visit?
- Could I get a placebo? What happens to my current treatment?
- What are the possible risks and benefits?
- Are travel or other costs covered?
- What happens after the trial ends?
Official details
| Status | Recruiting |
|---|---|
| Phase | Not applicable |
| Study type | Interventional |
| Conditions | Crohn Disease; Inflammatory Bowel Diseases (IBD); Ulcerative Colitis (Disorder) |
| Lead sponsor | Assistance Publique Hopitaux De Marseille |
| Enrollment | 60 (estimated) |
| Start date | 2025-07-24 |
| Primary completion (est.) | 2027-03-24 |
| First posted | 2025-02-03 |
| Last updated | 2026-09-21 |
| Official title | Study of Tissue Repair in Inflammatory Bowel Disease Exploiting Organoid Technology |
| ClinicalTrials.gov ID | NCT06805890 |
Interventions
- Colonoscopy - IBD inflamed tissue (Procedure)
Collection of 10 colonic biopsies in IBD inflamed tissue - Surgical resection - IBD inflamed mucous membrane (Procedure)
Collection of a portion of IBD inflamed mucous membrane - Colonoscopy - biopsies in healthy tissue (Procedure)
Collection of 10 colonic biopsies in healthy tissue - Surgical resection - healthy mucous membrane (Procedure)
Collection of a portion of healthy mucous membrane
Full eligibility criteria (from the record)
For IBD group the inclusion criteria will be: * Patients of either sex aged 18 years or older * Patient that have read the information form and signed consent * Patient covered with health insurance * Patients with Crohn's Disease or ulcerative colitis in accordance with accepted clinical, endoscopic, histological and/or radiologic criteria, regardless of the level, severity of the disease or duration of disease progression. * Patients with colonic involvement of Crohn's disease or ulcerative colitis * Patients undergoing a screening colonoscopy in the context of IBD disease follow-up OR undergoing intestinal resection for IBD disease aggravation For control group the inclusion criteria will be: * Patients of either sex aged 18 years or older * Patient that have read the information form and signed consent * Patient covered with health insurance * Patients undergoing a screening colonoscopy in the context of a family history of colonic neoplasia, follow-up of colonic polyps or functional intestinal disorders OR undergoing intestinal resection for intestinal neoplasia, occlusive syndrome or colostomy The non-inclusion criteria for IBD group will be: * Contraindication to the anaesthetic or colonoscopy procedure * Patients without colonic involvement of Crohn's disease or ulcerative colitis * Patients of Adults without legal capacity * Patients in Health and Social Establishments * Persons in emergency situations * Persons deprived of their liberty * Non-affiliated to a social security scheme * Absence or refusal of the informed consent The non-inclusion criteria for control group will be: * IBD disease revealed during colonoscopy or gastrointestinal resection * Patient suffering from Immune-Mediated Inflammatory Diseases (IMIDs) * Contraindication to the anaesthetic or colonoscopy procedure * Patients of Adults without legal capacity * Patients in Health and Social Establishments * Persons in emergency situations * Persons deprived of their liberty * Non-affiliated to a social security scheme * Absence or refusal of the informed consent
Locations (1)
| Site | City | Country | Site status |
|---|---|---|---|
| Nord Hospital | Marseille | France | Recruiting |
For contacts at each site, use the official record.
Information only, not medical advice. Talk to your doctor and the trial team before making any decision about a clinical trial.