Crohn'sRecruiting

Prediction of Postoperative Recurrence in Crohn's Disease

Observational · No treatment assigned · 1 site · Sixth Affiliated Hospital, Sun Yat-sen University

Official record & contacts on ClinicalTrials.gov ↗

In plain English

What this trial is testing

Condition(s) listed: Crohn Disease (CD) and Postoperative Recurrence and Metastasis. This is an observational study: researchers collect information (for example questionnaires, samples, or scans) but the study does not assign a treatment.

Who can join

Ages 18 to 70
Any sex

Some of the main requirements, copied from the record:

Crohn's Disease Cohorts:
Diagnosis of Crohn's disease according to the diagnostic criteria of the Chinese Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease (2018, Beijing).
Patients with Crohn's disease who require surgical resection of the diseased intestinal segment because of complications such as stricturing or penetrating disease, or because of failure of medical therapy.

Plus 2 more requirement(s). There are also 6 reasons someone might not be able to join (exclusion criteria). Only the trial team can confirm whether you qualify.

What's involved

About 250 participants are expected to take part.
Start date: 2025-07-22.
Main results expected around 2028-12 (estimate from the record).
1 study site listed (1 marked recruiting) in China.

Main thing being measured

Clinical Recurrence Rate at 6 Months (6 months after intestinal resection)

In the researchers’ words

This multicenter prospective observational cohort study aims to develop and validate a multimodal prediction model for postoperative recurrence in patients with Crohn's disease. Patients with Crohn's disease who undergo intestinal resection will be enrolled and followed after surgery.

This is a short automatic summary built from the official record. A fuller plain-English card is coming; until then, please read the official record.

Questions to ask your doctor and the trial team

Am I likely to qualify, given my health history?
What would I have to do, and how often would I need to visit?
Could I get a placebo? What happens to my current treatment?
What are the possible risks and benefits?
Are travel or other costs covered?
What happens after the trial ends?

Official details

Status	Recruiting
Phase	Observational
Study type	Observational
Conditions	Crohn Disease (CD); Postoperative Recurrence and Metastasis
Lead sponsor	Sixth Affiliated Hospital, Sun Yat-sen University
Enrollment	250 (estimated)
Start date	2025-07-22
Primary completion (est.)	2028-12
First posted	2026-09-17
Last updated	2026-09-17
Official title	Prediction Model and Molecular Mechanisms of Postoperative Recurrence in Crohn's Disease
ClinicalTrials.gov ID	NCT07824791

Interventions

Intestinal Resection (Procedure)
Participants undergo intestinal resection as clinically indicated as part of routine medical care. The surgical procedure is not assigned by the study protocol. Residual surgical tissue that would otherwise be discarded may be collected for research analyses.
Biospecimen Collection (Procedure)
Residual surgical tissue and biological samples are collected for research. Surgical tissue used for research consists of residual specimens remaining after routine clinical pathological examination. Samples may be used for transcriptomic, single-cell transcriptomic, spatial transcriptomic, proteomic, microbiome, metabolomic, and other multi-omics analyses.

Full eligibility criteria (from the record)

Inclusion Criteria:

* Crohn's Disease Cohorts:

  1. Diagnosis of Crohn's disease according to the diagnostic criteria of the Chinese Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease (2018, Beijing).
  2. Patients with Crohn's disease who require surgical resection of the diseased intestinal segment because of complications such as stricturing or penetrating disease, or because of failure of medical therapy.

Non-IBD Control Cohort:

1.Patients who require surgical resection of an intestinal segment because of conditions such as colorectal tumors or diverticular disease.

Exclusion Criteria:

* Crohn's Disease Cohorts:

  1. Uncertain diagnosis of Crohn's disease.
  2. Clinical history or medical records are substantially incomplete, making it impossible to determine the time of recurrence or whether postoperative recurrence occurred.

Non-IBD Control Cohort:

1. Coexisting inflammatory bowel disease or other rheumatic or autoimmune diseases.
2. Substantially incomplete clinical history or medical records.

Locations (1)

Site	City	Country	Site status
The Sixth Affiliated Hospital, Sun Yat-sen University	Guangzhou, Guangdong	China	Recruiting

For contacts at each site, use the official record.

Information only, not medical advice. Talk to your doctor and the trial team before making any decision about a clinical trial.